Botulinum toxin, depression, central adiposity, arsenic & loneliness. What on Earth could these 5 things have in common? They are all potential toxins for human beings. Young Australians are lonely, married Australians are lonely, 50% of Australians feel lonely at least one day a week and depression is projected to become the disease with the 2nd highest DALYs burden! Consequently, we as future health advocates ought to ask what we can learn about loneliness. Join us with Dr. Michelle Lim and Associate Professor Elisabeth Lambert, as we explore loneliness in Australia and consider a model for depression as a cardiotoxic state.